杭州楼凤

first_img How athletes protesting the national anthem has evolved over 17 years AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREUCLA alum Kenny Clark signs four-year contract extension with PackersTaking aggressive lanes to the rim, James looked to score early. He poured in 33 points, 19 in the first half alone, thanks to his array of offense from layups in traffic, to deep 3-pointers that taunted the deep-rooted Spurs tradition of going under on his screens.The fourth quarter sealed the Lakers’ case: James scored or assisted on the first 21 points of the period, including the first 10 points in the fourth after checking into the game. After ending their last three games with some suspense in the final minute, the hot streak from James, who finished with 14 assists (12 in the second half), gave the Lakers (15-2) enough of a cushion to ease to their eighth consecutive win.James finished 13 for 24 from the field and 4 for 7 on 3-pointers in 35 minutes. On an earlier night this season, it’s the kind of performance that would have been labeled “vintage LeBron James.” But leading the league in assists while providing nightly aerial highlights has rendered the term obsolete until further notice – he’s still in his prime.Even Coach Frank Vogel admitted he’s running out of meaningful things to say about James’ MVP-level performances.“He was unbelievable tonight,” he said. “I’m gonna need a thesaurus or something for more adverbs.” PreviousReferee Eric Lewis, left, and Los Angeles Lakers forward LeBron James (23) crash into the scorer’s table during the first half of an NBA basketball game against the San Antonio Spurs, in San Antonio, Monday, Nov. 25, 2019. (AP Photo/Eric Gay)Lakers forward Anthony Davis tries to pass the ball as he falls in font of Spurs guard DeMar DeRozan during the first half of Monday’s game in San Antonio. (AP Photo/Eric Gay)San Antonio Spurs guard DeMar DeRozan (10) shoots past Los Angeles Lakers forward Anthony Davis (3) during the first half of an NBA basketball game, in San Antonio, Monday, Nov. 25, 2019. (AP Photo/Eric Gay) SoundThe gallery will resume insecondsLos Angeles Lakers guard Rajon Rondo (9) shoots past San Antonio Spurs guard Dejounte Murray (5) during the first half of an NBA basketball game, in San Antonio, Monday, Nov. 25, 2019. (AP Photo/Eric Gay)San Antonio Spurs center LaMarcus Aldridge (12) shoots past Los Angeles Lakers forward Anthony Davis (3) during the first half of an NBA basketball game, in San Antonio, Monday, Nov. 25, 2019. (AP Photo/Eric Gay)Los Angeles Lakers forward LeBron James (23) scores past San Antonio Spurs forward Rudy Gay (22) during the first half of an NBA basketball game, in San Antonio, Monday, Nov. 25, 2019. (AP Photo/Eric Gay)Los Angeles Lakers forward LeBron James (23) and San Antonio Spurs guard DeMar DeRozan (10) during the second half of an NBA basketball game, in San Antonio, Monday, Nov. 25, 2019. (AP Photo/Eric Gay)Lakers forward LeBron James hangs on the rim after dunking for two of his game-high 33 points during the first half of Monday’s game against the Spurs in San Antonio. James added 14 assists in the 114-104 win. (AP Photo/Eric Gay)San Antonio Spurs guard Patty Mills (8) drives around Los Angeles Lakers forward Anthony Davis (3) during the first half of an NBA basketball game, in San Antonio, Monday, Nov. 25, 2019. (AP Photo/Eric Gay)Los Angeles Lakers forward LeBron James (23) is fouled as he drives to the basket between San Antonio Spurs guard DeMar DeRozan (10) and center Jakob Poeltl (25) during the second half of an NBA basketball game, in San Antonio, Monday, Nov. 25, 2019. (AP Photo/Eric Gay)San Antonio Spurs head coach Gregg Popovich, left, argues a call with referee Eric Lewis (42) during the first half of an NBA basketball game against the Los Angeles Lakers in San Antonio, Monday, Nov. 25, 2019. (AP Photo/Eric Gay)Los Angeles Lakers guard Talen Horton-Tucker (5) shoots past San Antonio Spurs guard Dejounte Murray (5) during the second half of an NBA basketball game, in San Antonio, Monday, Nov. 25, 2019. (AP Photo/Eric Gay)Los Angeles Lakers forward LeBron James (23) drives to the basket over San Antonio Spurs center Jakob Poeltl (25) during the first half of an NBA basketball game, in San Antonio, Monday, Nov. 25, 2019. (AP Photo/Eric Gay)San Antonio Spurs center LaMarcus Aldridge (12) drives around Los Angeles Lakers center Dwight Howard during the second half of an NBA basketball game, in San Antonio, Monday, Nov. 25, 2019. (AP Photo/Eric Gay)Los Angeles Lakers forward LeBron James (23) is fouled by San Antonio Spurs center Jakob Poeltl (25) during the first half of an NBA basketball game, in San Antonio, Monday, Nov. 25, 2019. (AP Photo/Eric Gay)San Antonio Spurs guard Dejounte Murray (5) shoots past Los Angeles Lakers forward LeBron James (23) during the second half of an NBA basketball game, in San Antonio, Monday, Nov. 25, 2019. (AP Photo/Eric Gay)Referee Eric Lewis, left, and Los Angeles Lakers forward LeBron James (23) crash into the scorer’s table during the first half of an NBA basketball game against the San Antonio Spurs, in San Antonio, Monday, Nov. 25, 2019. (AP Photo/Eric Gay)Lakers forward Anthony Davis tries to pass the ball as he falls in font of Spurs guard DeMar DeRozan during the first half of Monday’s game in San Antonio. (AP Photo/Eric Gay)NextShow Caption1 of 16Lakers forward Anthony Davis tries to pass the ball as he falls in font of Spurs guard DeMar DeRozan during the first half of Monday’s game in San Antonio. (AP Photo/Eric Gay)ExpandSAN ANTONIO — From the sharp tone LeBron James struck on Monday morning, it didn’t seem like his Lakers were preparing for a team that had lost eight of its nine previous games.While the Lakers have let other struggling teams hang around in the last week before winning anyway, James was wary of making the same mistake against the San Antonio Spurs.“It’s the same Spurs team I’ve played throughout my whole career,” he said. “They’re extremely well-coached. If you don’t go in with the mental side, they’ll beat the hell out of you.”On Monday night, it wasn’t the same old Spurs (6-12). But it was definitely the same LeBron James, who beat the hell out of a franchise that’s been one of the great foes of his career in the Lakers’ 114-104 victory. Lakers practice early hoping to answer all questions Lakers, Clippers schedules set for first round of NBA playoffs Trail Blazers beat Grizzlies in play-in, earn first-round series with the Lakers center_img Davis said he has a good idea of what to expect.“I’m pretty sure every time I catch the ball, it’s probably going to be boos and stuff like that,” he said. “As long as we stay locked in, as I stay locked in, and play the game the right way, and come out with a win, the rest of it doesn’t really matter.”That’s been the pattern so far three games into a four-game trip, which has been largely powered by James. He hit 30 for the second straight game, and passed Peja Stojakovic among all-time 3-point shooters on his final deep 3-pointer of the night to seize No. 18 with 1,761.It was the Spurs who sowed those seeds long ago, inspiring James to grow his game: In three NBA Finals clashes, two won by San Antonio, James felt challenged to seal up his weaknesses. Monday night was just the latest of that bitter harvest.“My first Finals appearance in ’07, they went under everything and I didn’t shoot the ball,” James said on the Spectrum broadcast. “I wasn’t comfortable with shooting the ball at that point in time in my career. I give a lot of thanks to their scheme, a lot of thanks to teams that I went against. Just trying to be the most complete basketball player I can be.” Trail Blazers, Grizzlies advance to NBA play-in game; Suns, Spurs see playoff dreams dashed Notably, James’ performance came on a cool night for Anthony Davis, who started just 2 for 10 from the field, looking hesitant to drive and settling for jumpers. But even he found his footing late, finishing with 19 points and 12 rebounds to help close out the game.On the other end, Davis helped shut down LaMarcus Aldridge late, as the Lakers held the Spurs star to a scoreless fourth after he went off for 30 in the first 36 minutes. DeMar DeRozan (24 points) matched James’ 12 points in the final frame, but couldn’t produce the same kind of playmaking – James had five assists in the fourth, from a sailing lob for a JaVale McGee dunk, to a closing dunk for Davis.The Lakers haven’t lost a game away from Staples Center, starting the season 7-0 when they leave their own building. The win Monday helped build momentum for a much-anticipated game on Wednesday night, when Davis returns to New Orleans to play the Pelicans, who traded him to the Lakers this summer.Related Articles Newsroom GuidelinesNews TipsContact UsReport an Errorlast_img read more

first_imgMANCHESTER — Around 20 Iowa communities are hosting local employers and state leaders this fall for what are known as Future Ready Iowa summits.Iowa Workforce Development director Beth Townsend says it’s an ideal opportunity to discuss Governor Kim Reynolds’ goal of continuing to build a skilled workforce in Iowa. Townsend says, “Future Ready Iowa is the initiative to align our workforce and education program so we can get 70% of Iowans between 25 and 64 upscaled and trained to have post-secondary credentials by 2025.”Townsend says one goal of the summits is to get business leaders to sit down with their counterparts from within the same community in order to discuss what’s working. “You had local employers coming in to talk to other local employers about the benefits of work-based learning programs in their facilities, or working with the disabled, or recruiting from communities you may not have otherwise thought about recruiting from,” Townsend says. “It’s been a great way to share those success stories.”The most recent Future Ready Iowa summit was held this past Friday in Manchester. Townsend says all of the attendees were encouraged to keep moving forward. “I am hoping that we’ll have employers who want to access and leverage the Employer Innovation Fund and put in an application to get some assistance or a match to help them address a barrier to training here in the community,” Townsend says. “It’s a program that’s going to keep going. We’re going to meet our goal by 2025 so we’re going to stay engaged.”The summits began in September and will run into November. Upcoming summits are planned in: Cedar Falls on Tuesday, Indianola on Wednesday, Spencer on Thursday, Davenport on Friday, and in the coming weeks in: Jefferson, Conrad, Carter Lake, Cedar Rapids, Garner, Orange City, Ida Grove, Farley, Chariton, Cherokee and Ames.last_img read more

first_imgLeicester City put one hand on the Premier League trophy with a 2-0 win against Sunderland at the Stadium of Light.After a flat and tired performance in the first half, Jamie Vardy – who had previously been anonymous in terms of chances – showed his clinical ability in the box to fire the visitors ahead after 66 minutes. He then sealed the victory in stoppage time when he rounded the goalkeeper to send the travelling fans into hysterics. The league leaders move onto 72 points with five games remaining and they need just three more wins to seal the title.Ranieri named an unchanged side for the trip to Wearside to face Sam Allardyce’s relegation battlers. The identity of his team has remained the same for the majority of the season and that is one of the contributors to their success to date.Wes Morgan had the best chance of the first half when he met Christian Fuchs’ corner, glancing from the near post across the face of goal.City were appealing for a penalty before the interval as Shinji Okazaki was caught by DeAndre Yedlin in mid-air. Referee Anthony Taylor waved away appeals and the final action of the half saw Kasper Schmeichel produce a stunning save to deny Fabio Borini’s deflected shot.Leicester began to liven up in the second period and it took them 21 minutes to open the scoring. It came through yet another pacey counter attack. Danny Drinkwater’s long ball over the top was met by Vardy, who coolly converted past Vito Mannone from a tight angle.Sunderland could have been back on level terms in the closing stages of the game as Jack Rodwell squandered a big opportunity – blasting a six-yard effort over the crossbar.As the league leaders headed for a fifth 1-0 win in a row, Vardy rounded the goalkeeper in added time to roll the ball into an empty net for his 21st goal of the campaign.Before Spurs’ home match with Manchester United, the 2-0 result saw Leicester go ten points clear in an incredible campaign for the East Midlands club. READ MORE – Jose Mourinho hopes Claudio Ranieri will win the Premier League with Leicester City: ‘He deserves it, I like him very much’ Jamie Vardy takes his goal tally for the season to 21 2 2last_img read more

first_img23 February 2005South Africa will soon have a brand new high-capacity port. Developers say Ngqura, a multi-user deepwater port on the Coega River, and part of the multi-billion rand Coega industrial development zone (IDZ), is rapidly taking shape.The government is spending about US$400-million on the port – and other improvements in and adjacent to the Coega IDZ.Construction on the port is already far advanced, and the facility is expected to be ready for commercial traffic by the end of 2005. It will have a capacity for accommodating bigger container vessels than any of South Africa’s seven other commercial ports.The filling up of the Ngqura harbour basin was completed in July 2004, which means that 5.75-million cubic metres of water have now replaced the 14-million cubic metres of beach sand that were removed.With the depth of the channel and the protected position in Algoa Bay, the port is in one of the best spots for a harbour along the South African coast.A channel carved by an ancient glacier allowed the development of the port to up to 23 metres. Protected from south-westerly winds by a finger of land, the port’s bay has 330 anchor days per year.Coega’s cutter suction dredger finished cutting an approach channel into the basin in December, meaning that the water in the basin now rises and falls in time with the tide.“With the quay walls complete, the successful filling of the harbour basin in July last year, the dredging finished, and the steady progress of the breakwaters, our main focus at the moment is the positioning of the concrete structures [caissons]”, said National Ports Authority resident engineer Chris Matchett.Matchett said the caissons were towed into position using tugboats and positioned by a system of anchors and winches before being flooded and sunk on prepared stone foundation beds.SouthAfrica.info reporterlast_img read more

first_imgRonald Mascariñas, president and general manager of Bounty Agro Ventures Inc. Photo by Mark Giongco/INQUIRER.netWith the PBA still yet to resolve issues in the Board of Governors, Ronald Mascariñas, Bounty Agro Ventures Inc. president, bared that the Chooks-to-Go brand has decided to abandon its plans of pursuing its own PBA team to exert all of its efforts in helping the national team.“The last few months of our association with Gilas gave us the realization that it’s best for us to put all our resources behind the national team,” Mascariñas said.ADVERTISEMENT View comments QC cops nab robbery gang leader, cohort Japan ex-PM Nakasone who boosted ties with US dies at 101 Stronger peso trims PH debt value to P7.9 trillion Boy Sablan out as UST coach Kris Aquino ‘pretty chill about becoming irrelevant’ CPP denies ‘Ka Diego’ arrest caused ‘mass panic’ among S. Tagalog NPA Mascariñas expressed interest in acquiring a PBA franchise before, but the amiable executive had a change of heart after repeated attempts and instead, reaffirmed its partnership with the Samahang Basketbol ng Pilipinas (SBP) going forward.Chooks-to-Go has been a primary supporter of SBP’s programs, from the grassroots level in age group 3×3 tournaments to sponsoring the national team in international tournaments like the Jones Cup and the Southeast Asian Games.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutoutThe poultry company has also went on to field a squad in the 2017 Fiba Asia Champions Cup in Chenzhou, China, with prospective naturalized import Isaiah Austin, together with this year’s first rounders Kiefer Ravena, Raymar Jose, and Jeron Teng bannering Chooks-to-Go Pilipinas.“Even if we had limited time to practice, coach Chot (Reyes) was able to assemble a very strong team,” said Mascariñas. Philippines reaffirms commitment to United Nations PLAY LIST 02:50Philippines reaffirms commitment to United Nations00:50Trending Articles00:50Trending Articles01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Gamescenter_img LATEST STORIES Brace for potentially devastating typhoon approaching PH – NDRRMC MOST READ Deciding to go all in with the SBP, Chooks-to-Go will continue to give its all out support for Smart Gilas Pilipinas in the 2019 Fiba World Cup Asian qualifiers, which starts on Friday against Japan in Tokyo. Chooks-to-Go will also rally behind Gilas in the upcoming 2018 Fiba 3×3 World Cup which will be staged here in Manila. Kammuri turning to super typhoon less likely but possible — Pagasa Read Next Don’t miss out on the latest news and information. Typhoon Kammuri accelerates, gains strength en route to PHlast_img read more

first_img Continue Reading Previous congatec: new SMARC module with NXP i.MX 8M Mini processorNext Yamaichi showcases CEI-112G interoperability live demo at ECOC 2019 Card payment terminals are about to become even more affordable and ubiquitous with a new single-chip controller developed by STMicroelectronics and mobile payment solutions disruptor YouTransactor. Combining YouTransactor’s market knowledge and intellectual property of security and point-of-sale payment terminals and applications, with ST’s chip-design skills and intellectual property including cyber-protection and sophisticated display-graphics control, the new chip is the first PCI secure SoC for mobile payment terminals to be based on a general-purpose microcontroller for robust performance and low power at a cost-effective price.The new System-on-Chip, the YTSECPCI, is commercialized by YouTransactor with the support of ST and is available to customers on flexible delivery terms from YouTransactor, subject to Non-Disclosure Agreement. Launched last month, the YTSECPCI has already been embedded and deployed in 50,000 payment terminals, with over 1 million units ordered for 2019-2020, reflecting the strong demand of the retail industry for low-cost secure payment devices.As a fully integrated System-on-Chip (SoC) with a PCI (Payment Card Industry) kernel, the new device embeds all the physical security mechanisms required by PCI PTS (Pin Transaction Security) to ensure the safety of transactions and user data. These include mesh monitoring, switch monitoring, support for secure application loading and secure boot, advanced cryptographic libraries, active software and hardware tamper detection with data-erase, card-data and pin-code protection, key management, and real-time clock integrity protection.Contact and contactless payment modes are all supported, and the chip comes pre-certified to PCI specifications to ease final approval of customers’ products. In addition to mobile point-of-sale (POS) terminals, the SoC can also be integrated in devices such as vending machines, IoT, cash registers, smartphones or retail hardware.The chip leverages the advanced features and ultra-low-power technologies of ST’s STM32L4 microcontrollers. Highlights of the MCU include 100DMIPS/273CoreMark processing performance, multiple power-management modes to help minimize overall energy consumption, large on-chip data and program memory, and ST’s unique Chrom-ART Accelerator to handle sophisticated user-interface graphics.In addition, engineering teams benefit from the extensive STM32 development ecosystem, including initialization tools, free essential middleware and software, and graphical development tools available through the ST Partner program.To further aid development and accelerate time to market for innovative payment devices, ST and YouTransactor have also created a dedicated evaluation board and reference design containing the YTSECPCI. For further information and to discuss terms for availability, please contact YouTransactor or your local ST sales office.Share this:TwitterFacebookLinkedInMoreRedditTumblrPinterestWhatsAppSkypePocketTelegram Tags: Chips & Components last_img read more

first_img Patient history, from the perspective of both the patient and another trusted source The patient’s physical appearance before clean-up or treatment is initiated A head-to-toe evaluation for injuries All injuries, including minor ones Any evidence that might disprove abuse or neglect (pertinent negatives) “The need to protect our older loved ones from elder abuse is great,” says Alexis Coulourides Kogan, PhD, assistant professor of family medicine at the Keck School and co-author of the study. “But focusing solely on the reason for a patient’s visit seldom tells the whole story, even when you look at the medical chart. If documentation of physical findings is poor, then we may be missing the big picture.”Study participants also noted the value of photographs and body diagrams to supplement written documentation, the time challenges of thorough documentation in a busy clinical setting and the need to integrate the tool into existing electronic medical records.”It may be more work for a clinician to use an injury documentation tool, but we believe the value far surpasses the burden placed on physicians,” Kogan explains. “If there is suspected elder abuse, these records can potentially help prosecutors achieve justice and protection for older adults or exonerate innocent caregivers.”Next, the researchers plan to seek funding to test the Geriatric Injury Documentation Tool in clinical settings.Source: https://www.keckmedicine.org/ Reviewed by James Ives, M.Psych. (Editor)Feb 15 2019Experts develop first standardized framework for clinicians to document physical findings on older patientsAn estimated 10 percent of older adults experience some form of abuse each year. However, the link between injuries and possible elder abuse may take months or years to establish and is often difficult to investigate due to poor documentation during prior medical visits.Geriatric experts now hope to standardize the process of documenting physical injuries on older adult patients and make the medical record more thorough with the creation of the Geriatric Injury Documentation Tool (Geri-IDT). The tool emerged from a new study led by Laura Mosqueda, MD, dean of the Keck School of Medicine of USC and professor of family medicine. The study confirms the need for improved documentation, detailing what experts believe are the most effective factors to achieve it.Results of the study were presented today in the Journal of General Internal Medicine. The study was informed by interviews with elder abuse experts across the United States, including physicians, detectives and prosecutors, and focus groups with clinicians at emergency medicine and primary care sites.”Because older adults are more vulnerable to injuries like fractures and bruising, it is often difficult to distinguish if an injury is due to an accident or abuse,” says Mosqueda, who is also director of the National Center on Elder Abuse. “This tool includes diagrams and a brief questionnaire that makes it easier to document an injury and reminds clinicians about what to ask and observe during the exam. We believe this will move us toward more comprehensive injury documentation and ultimately result in better medical care.”Related StoriesResearch sheds light on sun-induced DNA damage and repairTAU’s new Translational Medical Research Center acquires MILabs’ VECTor PET/SPECT/CTScientists develop universal FACS-based approach to heterogenous cell sorting, propelling organoid researchExperts confirmed that current documentation of geriatric injuries is usually inadequate for investigating alleged elder abuse and neglect. As such, they highlighted the need for documenting:last_img read more

first_imgReviewed by James Ives, M.Psych. (Editor)May 30 2019Kratom is a Southeast Asian tree with a long history of use in traditional medicine. In the region, the plant’s leaves are widely consumed for pain relief, treatment of opioid addiction and other uses. Though its efficacy and safety are unproven, kratom use has spread to the U.S. and Europe. Now, researchers report in ACS Central Science that a metabolite of a kratom alkaloid could be responsible for the treatment’s therapeutic effects.Currently, kratom is legal and available in the U.S. as a gray-market product, but it has an uncertain regulatory future. In the meantime, scientists are investigating the substance’s physiological effects. Some prior research attributed these effects to mitragynine, the major active alkaloid in kratom, and its binding to an opioid receptor. However, 7-hydroxymitragynine (7-OH), another alkaloid present in the leaf at far lower concentrations, also interacts with that receptor. To clear up the matter, Jonathan A. Javitch, Susruta Majumdar, Dalibor Sames and colleagues set out to probe the pharmacological and metabolic mechanisms behind kratom’s analgesic effects.Related StoriesCreating a physical and genetic map of Cannabis sativaNew computational model explores daily pain sensitivity rhythmsCase study: Cannabinoid hyperemesis syndrome in a patient with ALSThrough studies in cells and mice, the researchers showed that most of the analgesic effect is from 7-OH rather than mitragynine. They also found that metabolism of mitragynine in mouse and human liver preparations actually produces much more 7-OH than is present naturally in kratom. The team says that the results shed light on some of the seemingly contradictory reports on kratom, but more studies are still needed to see whether their findings in mice extend to humans.Source:American Chemical SocietyJournal reference:Kruegel, A.C. et al. (2019) 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects. ACS Central Science. doi.org/10.1021/acscentsci.9b00141.last_img read more

first_imgReviewed by James Ives, M.Psych. (Editor)Jul 4 2019Findings published today in the journal Science Translational Medicine suggest that a type of white blood cell called tumor associated macrophages (TAMs) that have been deceived by pancreatic cancer cells into not attacking them can be “re-programmed” by a specially designed molecule that activates a protein found on their surfaces.Researchers hope that this immune system boosting molecule — ADH-503–can eventually also make the checkpoint inhibitor immunotherapies that revolutionized the treatment of many cancers available to pancreatic cancer patients. Pancreatic cancer is the third deadliest cancer in the United States, but has shown to not respond to most current immunotherapies.The paper “Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies” was collaboration between Washington University School of Medicine in St. Louis and Rush University Medical Center in Chicago. Co-senior authors are David DeNardo, PhD, an associate professor of medicine and of pathology and immunology at Washington University and Vineet Gupta, PhD, of Rush’s Vice Chair for Research and Innovation in the Department of Internal Medicine.The authors describe how the novel ADH-503 compound interferes with the migration and polarization of myeloid cells – a type of immune system cell that circulates through the body identifying and attacking pathogens like cancer. One type of myeloid cell called macrophages (Greek for “big eaters”) that are present in the tumors were a particular focus, as cancer cells are especially adept at disrupting the processes in which macrophages are able to control tumor growth.In myeloid cells, including macrophages, a receptor protein called CD11b plays a central role in recruiting them to tumors and in detecting threats and signaling whether the immune system should respond. In pancreatic cancer tumors, the number of macrophages that help tumors grow far outnumber those that suppress them.Related StoriesSpecial blood test may predict relapse risk for breast cancer patientsSugary drinks linked to cancer finds studyBacteria in the birth canal linked to lower risk of ovarian cancerADH-503 binds with and activates the CD11b receptor proteins on the myeloid cell surface. When the researchers orally delivered the ADH-503 compound to mice with pancreatic cancer, the number of myeloid cells in and near the tumors dropped, and the remaining myeloid cells were shown to be ones that promoted, rather than suppressed, immune responses. This environment translated into greater numbers of cancer-killing T cells in the tumor, significantly slower tumor growth and longer survival. We believe these data demonstrate that targeting the CD11b receptor with a novel molecule can decrease TAM density and reprogram myeloid cell responses to reduce tumor growth. It also overcomes resistance to T-Cell mediated therapies.”Vineet Gupta, PhD The researchers then investigated whether creating this same environment could make pancreatic tumors susceptible to standard immunotherapy. First, they treated a control group of mice with checkpoint inhibitor (PD-1 inhibitor) immunotherapy used to treat other kinds of cancer. There was no measurable effect. But when the therapy was combined with the ADH-503 compound, the tumors shrank and the mice survived significantly longer.While pancreatic cancer is the third leading cause of cancer-related death in the United States, only 89 of more than 2,600 (or about 3%) 2,600 cancer immunotherapies clinical trials target pancreatic cancer”Pancreatic cancer is a highly lethal disease and we are in desperate need of new therapeutic approaches,” said DeNardo. “In animal studies, this small molecule led to very marked improvements and was even curative in some cases. We are hopeful that this approach could help pancreatic cancer patients.”Phase 1 clinical trials are planned by Gossamer Bio, Inc for the middle of this year. Source:Rush University Medical Centerlast_img read more

first_img Japan’s Hitachi freezes British nuclear project The Wylfa Newydd nuclear power station was estimated to cost 300 billion yen ($2.7 billion) © 2019 AFP Hitachi’s frozen nuclear power project in Britain can only be revived if it is nationalised, the Nikkei business paper reported the company’s chairman as saying on Wednesday. Citation: Hitachi wants nationalisation of UK nuclear project: report (2019, January 24) retrieved 17 July 2019 from https://phys.org/news/2019-01-hitachi-nationalisation-uk-nuclear.htmlcenter_img “Nationalisation is the only path,” Hiroaki Nakanishi was quoted as saying at the World Economic Forum in Davos.But he added that legal changes would be required for the British government to take a majority stake in the business to fill a funding gap left by the private sector.The chairman said private investors had little appetite to support the power plant after seeing similar projects around the world stall, Nikkei reported.Hitachi last week froze construction of the Wylfa Newydd plant in Wales owing to financing difficulties.It had launched the project after acquiring British-based Horizon Nuclear Power in 2012.The UK government had agreed to take a one-third equity stake in the project, alongside investment from Hitachi, Japanese government agencies and other strategic partners. Fund-raising efforts subsequently fell short, however.Britain has put nuclear power at the heart of its low-carbon energy policy, in stark contrast to Europe’s biggest economy Germany, which is phasing it out in the wake of Japan’s 2011 Fukushima nuclear disaster.Last year, Hitachi’s Japanese rival Toshiba also pulled the plug on a nuclear power plant project in northwest England.The Franco-Chinese project Hinkley Point C —Britain’s first new nuclear power station in a generation—is still under construction meanwhile.British anti-nuclear campaigners have long denounced London’s steadfast commitment to nuclear, urging it to focus instead on renewable sources like wind and solar.”A clever move now would be for the government to accept that the nuclear bet didn’t pay off, stop holding back renewables and have an urgent rethink about the future of UK energy,” Doug Parr, chief scientist for Greenpeace UK said earlier. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more